University of Minnesota
School of Physics & Astronomy

Biophysics Seminar

Thursday, February 7th 2019
10:10 am:
Biophysics Seminar in 120 PAN
Speaker:  Karunya Kandimalla, Associate Professor at Department of Pharmaceutics of the University of Minnesota
Subject: Nanovehicles for the Diagnosis and Treatment of Blood-Brain Barrier Dysfunction in Neurodegenerative Diseases

The blood brain barrier (BBB) performs dual functions of restricting the entry of xenobiotics into brain while serving as the major signaling and material trafficking portal between plasma and brain. Moreover, the BBB modulates cerebral blood flow to sustain neuronal activity; handles glucose as well as insulin delivery to brain; and maintains immune and inflammatory communication between periphery and brain. These critical BBB functions are disrupted in neurodegenerative disease like Alzheimer’s disease and cerebral amyloid angiopathy. We developed therapeutic nanoparticles to detect and treat BBB dysfunction in these diseases.
For successful brain delivery, a nanoparticle must withstand dominant clearance pressure from the peripheral reticuloendothelial system, marginate from the bulk blood flow to the vascular endothelium, permeate the blood-brain-barrier, and accumulate at the target site. In addition to these common challenges, the nanoparticles intended for cerebrovascular targeting must incorporate appropriate design elements to ensure their retention in the cerebral vasculature. Furthermore, a functionally optimized nanoparticle design demands synergistic amalgamation of the physicochemical properties of various components and their intended physiological effects. Strategies developed in our laboratory to surmount these barriers will be discussed in the talk.

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