University of Minnesota
School of Physics & Astronomy

Physics and Astronomy Calendar

Tuesday, October 21st 2014
2:30 pm:
Biophysics Seminar in 210 Physics
Speaker: Ben Hackel, University of Minnesota
Subject: Engineering Synthetic Ligands for Molecular Imaging

Non-invasive in vivo imaging at the molecular and cellular scale has transformative clinical potential for the detection, characterization, and monitoring of disease. Molecular imaging necessitates command of molecular recognition, molecular biology of the target, biological transport at the tissue and cellular levels, and detection technology. While the seminar will briefly touch on improved understanding and technological advancement in each of these elements, the focus will be on engineering synthetic binding ligands as molecular targeting agents. In particular, I'll discuss our algorithm to efficiently evaluate naturally occurring protein domains for their potential evolutionary capacity and the resultant development of a small (45 amino acid) scaffold capable of efficient evolution of novel, high affinity binding functions.

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