University of Minnesota
School of Physics & Astronomy

Physics and Astronomy Calendar

Thursday, March 1st 2018
10:10 am:
Biophysics Seminar in 120 PAN
Speaker: Tanner Akkin, Associate Professor of Biomedical Engineering, University of Minnesota
Subject: Development of a Serial Optical Coherence Scanner for Visualizing and Mapping the Brain with Microscopic Resolution

The feasibility of mapping and imaging the brain with microscopic resolution is presented. A serial optical coherence scanner, which combines a polarization-sensitive optical coherence tomography and a tissue slicer, distinguishes white matter and gray matter and visualizes nerve fiber tracts that are as small as a few tens of micrometers. The technique utilizes the retardance contrast that arise due to the myelination of nerve fibers and the axis orientation contrast that determine the 2D orientation of the nerve fibers, and the technique can be adapted to measure the inclination angle of the fiber, completing the 3D orientation. This scanner could reveal biomarkers for disease onset and progression, and support development of therapeutics.

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