University of Minnesota
School of Physics & Astronomy
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Jochen Mueller


PAN 418 (office), 625-4369
mueller @

Session Chair, 5th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine (2002); Member of “Single cell / Single molecule” focus group as part of CBISC (Steering Committee of the Chemical Biology Initiative (2004); Panel Member, MPS-MCB Review, NSF (2004); Session Chair, 6th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine (2005); Panel Member, Biological Physics Review, NSF (2006); Member of the Graduate Research Advisory Committee (GRAC), Graduate School, University of Minnesota, (Spring 2006 – current); Organizer of Annual Hands-On Fluorescence Workshop for Students of Biological Sciences (2006 – current);

Summary of Interests
Experimental biophysics, two-photon excitation microscopy, fluorescence fluctuation spectroscopy

Advisees and Collaborators

Christopher Angert, Research Assistant
Yan Chen, Research Associate
John Eichorst, Post-Doctoral Fellow
Jared Hennen, Teaching Assistant
Kwang Ho Hur, Research Assistant
Siddarth Reddy Karuka, Teaching Assistant
John Kohler, Teaching Assistant
Patrick Macdonald, Research Assistant
Elizabeth Smith, Research Assistant

Selected Publications

J. P. Skinner, Y. Chen, and J. D. Mueller, Fluorescence Fluctuation Spectroscopy in the Presence of Immobile Fluorophores,", Biophys J (2008)

B. Wu, Y. Chen, and J. D. Mueller, Fluorescence Correlation Spectroscopy of Finite-Size Particles,”, Biophys J (2008)

B. P. Duckworth, Y. Chen, Y. Sham, J. D. Mueller, T. A. Taton, and M. D. Distefano, A Universal Method for the Preparation of Covalent Protein-DNA Conjugates for Use in Creating Protein Nanostructures,", Chem., Int. Ed.(2007)

Y. Chen and J. D. Müller, Determining the Stoichiometry of Protein Hetero-complexes in Living Cells with Fluorescence Fluctuation Spectroscopy,", Proc. Natl. Acad. Sci. USA (2007)

L. N. Hillesheim, Y. Chen, and J. D. Mueller, Dual-Color Photon Counting Histogram Analysis of mRFP1 and EGFP in Living Cells,", Biophys J (2006)

Y. Chen, M. Tekmen, L. N. Hillesheim, J. Skinner, B. Wu, and J. D. Müller, Dual-Color Photon Counting Histogram, Biophys. J. (accepted) 2005

M. Tekmen and J. D. Müller, High-Pressure Cell for Fluorescence Fluctuation Spectroscopy, Rev. Sci. Instr., 75, 5143-5148 (2004).

J. D. Müller, M. Tekmen, L. N. Hillesheim, W. Yang, and Y. Chen, Dual-Color Fluorescence Fluctuation Spectroscopy in vitro and in vivo, SPIE Proc. 5323, 136-145 (2004).

J. D. Müller, Cumulant analysis in fluorescence fluctuation spectroscopy, Biophys. J. 86(6), 3981-3992 (2004).

Y. Chen, L. N. Wei, and J. D. Müller , Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy, Proc. Natl. Acad. Sci. USA 100(26), 15492-15497 (2003).

L. N. Hillesheim and J. D. Müller, The Photon Counting Histogram in Fluorescence Fluctuation Spectroscopy with Non-ideal Photodectors, Biophys. J. 85, 1948-1958 (2003).

J. D. Müller, Following protein association in vivo with fluorescence fluctuation spectroscopy, SPIE Proc. 4963, 24-31 (2003).

J. D. Müller and E. Gratton, High-Pressure Fluorescence Correlation Spectroscopy, Biophys. J. 85(4), 2711-2719 (2003).


Ph.D., Technical University of Munich, 1997