University of Minnesota
School of Physics & Astronomy
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Elias Puchner

Single molecule techniques - Applications in biology
Elias M. Puchner (Editorial), FEBS Letters Special Issue 588(19 ), 3519-3648 (2014)

Download from http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2014.08.020/full

Abstract

Techniques with single molecule sensitivity have been greatly improved in the past decades. For example, the introduction of novel nanostructures increased the sensitivity of fluorescence-based single molecule imaging, whereas in vivo applications of this approach have also been extended. In addition, recent advances have significantly enhanced the speed and precision of atomic force microscopy and force spectroscopy. This Special Issue highlights the increasing sophistication and robustness of single molecule techniques, which emerge as crucial tools for elucidating biological processes at utmost detail and accuracy.