University of Minnesota
School of Physics & Astronomy
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Michael Garwood

MB-SWIFT Functional MRI during Deep Brain Stimulation in Rats
L.J. Lehto, D. Idiyatullin, J. Zhang, L. Utecht, G. Adriany, M. Garwood, Olli Gröhn, S. Michaeli, and S. Mangia, NeuroImage 159:443-448, 2017

Download from https://doi.org/10.1016/j.neuroimage.2017.08.012

Abstract

Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having virtually zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's brain at 9.4 T during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows functional images free of susceptibility artifacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast. MB-SWIFT fMRI modality permits activation studies in the close proximity to an implanted lead, which is not possible to achieve with conventionally used gradient echo and spin echo - echo planar imaging fMRI techniques. We conclude that MB-SWIFT fMRI is a powerful imaging modality for investigations of functional responses during DBS.