University of Minnesota
School of Physics & Astronomy

Biophysics Seminar

Thursday, February 15th 2018
10:10 am:
Biophysics Seminar in 120 PAN
Speaker: Jasmine Foo, School of Mathematics, University of Minnesota
Subject: Impact of the tumor microenvironment on drug resistance in cancer

Despite the effectiveness of many therapies in reducing tumor burden during the initial phase of treatment, the emergence of drug resistance remains a primary obstacle in cancer treatment. Tumors are comprised of highly heterogeneous, rapidly evolving cell populations whose dynamics can be modeled using evolutionary theory. In this talk I will describe some mathematical models of the evolutionary processes driving drug resistance in cancer, and demonstrate how these models can be used to provide clinical insights. These models will be applied to study the impact of dosing schedules and the tumor microenvironment on the emergence of drug resistance in lung cancer.

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