University of Minnesota
School of Physics & Astronomy

Biophysics Seminar

Thursday, May 2nd 2019
10:10 am:
Biophysics Seminar in 120 PAN
Speaker: Prof. Louis M. Mansky, Director, Institute for Molecular Virology, University of Minnesota
Subject: "Biophysical and Molecular Studies of Human Retroviral Assembly"

An underexplored aspect of human retrovirus replication are the steps involved in virus particle assembly. In particular the behavior of Gag movement to the plasma membrane, the engagement of particle budding sites, the molecular Gag-Gag interactions that create the immature Gag lattice, and subsequent particle biogenesis and morphogenesis remain poorly understood. Detailed comparative analysis of close relatives can be highly informative for gaining new insight into these steps in virus replication. Our interdisciplinary collaborative research team has made key observations regarding the differences in the pathways for Gag nucleation leading to punctum formation, as well as the nature of particle biogenesis also remain poorly understood aspects of the retrovirus assembly pathway, particularly among human immunodeficiency virus type 1 and its close relatives – i.e., human immunodeficiency virus type 2 (HIV-2) and human T-cell leukemia virus type 1 (HTLV-1). This lecture will discuss ongoing collaborative studies regarding 1) a comparative analysis of immature and mature virus particles and 2) an investigation of the nature of human retrovirus particle biogenesis. To date, our observations provide new insights into a highly significant and poorly understood aspect of the human retroviral life cycle, which has utility in informing intervention strategies.

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