University of Minnesota
School of Physics & Astronomy

Biophysics Seminar

Thursday, February 14th 2019
10:10 am:
Biophysics Seminar in 120 PAN
Speaker: Jiali Gao, Department of Chemistry, University of Minnesota
Subject: Allosteric Regulation of Biological Function of Photoreceptor proteins

Major light-harvesting complex of photosystem II (LHCII) is a photoreceptor protein that regulates energy transfer and dissipation in response to rapid fluctuations of light intensity, directly affecting the efficiency of photosynthesis. In this presentation, I will describe an investigation combining molecular dynamics simulation and temperature-jump time-resolved IR spectroscopy to understand the mechanism of energy dissipation in LHCII. I will illustrate an allosteric regulation of the global protein conformational changes induced by a local conformational transition of random coils into α-helices due to changes of external temperature and acidity. The dynamic motions induce close contacts between the associated luteins (Lut) and photoactivated chlorophyll (Chl) chromophores to facilitate fluorescence quenching. In addition, I will discuss a multistate density functional theory designed to model photochemical and charge transfer processes.

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