University of Minnesota
School of Physics & Astronomy

Physics and Astronomy Calendar

Thursday, October 12th 2017
10:10 am:
Biophysics Seminar in 120 PAN
Speaker: Wendy Gordon, Dept. of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota
Subject: Decoding mechanotransduction mechanisms of cell-surface receptors

Alteration of mechanical forces is an emerging factor in diseases like cancer. Changes in macroscopic stiffness in disease are accompanied by a wealth of changes in a cell’s tensional homeostasis at a molecular level where mechanotransduction signaling pathways are aberrantly activated. Our lab aims to understand molecular mechanisms utilized by cell-surface receptors to sense and respond to physical stimuli in the cellular environment. I will discuss a new bioluminescence resonance energy transfer (BRET)-based molecular tension sensor that we have developed to help identify mechanosensing proteins in the cell. I will also discuss the molecular mechanisms utilized by the extracellular matrix receptor dystroglycan to regulate proteolysis.

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