University of Minnesota
School of Physics & Astronomy

Physics and Astronomy Calendar

Thursday, November 15th 2018
10:10 am:
Biophysics Seminar in PAN 120
Speaker: John Marko, Northwestern University
Subject: Single-molecule studies of protein-DNA interactions

All processing of DNA - transcription, replication, recombination and
repair - depend on the interactions of proteins with DNA. I will discuss
single-molecule methods for analyzing protein-DNA interactions, starting
with the (statistical)-mechanical response of DNA molecules and how
monitoring that can allow novel quantitative studies of proteins that fold
and change topology of DNA molecules. I will then describe a phenomenon
that appears pervasive for biomolecule interactions - "facilitated
dissociation" - that makes rates of turnover of molecular complexes in vivo
very different from what we observe in vitro.

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