University of Minnesota
School of Physics & Astronomy
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Michael Garwood

Professor Radiology-CMRR

CMRR 102 (office), 626-2001
gar @ umn.edu

Garwood2.jpg

Academy of Medical Device Innovators, Institute of Engineering in Medicine, University of Minnesota, 2016; Malcolm B. Hanson Endowed Chair in Radiology, 2016-; Lillian Quist – Joyce Henline Endowed Chair of Biomedical Research, 2003-2016; Associate Director, Center for Magnetic Resonance Research, 2003-; Fellow, International Society of Magnetic Resonance in Medicine, 2000; Scholar Award, Radiological Society of North America, 1989; Gold Medal, International Society of Magnetic Resonance in Medicine, 2007.

Summary of Interests
Development of advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques using ultrahigh magnetic fields. The design of amplitude- and frequency-modulated RF pulses to overcome experimental imperfections resulting, for example, from magn

About My Work

My laboratory is developing new spin physics and image acquisition techniques in magnetic resonance imaging (MRI). Our main objective is to enhance MRI’s capabilities and accessibility for research and medical diagnosis. Currently, we are developing a first-of-its-kind MRI system that opens new frontiers for human brain research, particularly in terms of better understanding human behavior and motor coordination. Specifically, we are building a small, portable MRI scanner for human brain research which will allow the subject’s body from the shoulders down to remain outside the magnet bore. Much of MRI technology that makes this MRI scanner possible originated in my laboratory after decades of research and breakthroughs in our understanding of frequency-modulated (FM) pulses and spatiotemporal encoding. For the past decade, we have had a focus on spatiotemporal encoding as a means to overcome a significant limitation of MRI, which is its intolerance of magnetic field inhomogeneity. My co-workers and I were the first to show the capability of spatiotemporal-encoded MRI to provide tolerance to magnetic field inhomogeneity in functional imaging (fMRI) studies of human brain. We also conceived of the novel technique known as SWIFT and were the first to show how it is possible to observe brain activity with no echo (TE=0). Also, using SWIFT, my colleagues and I showed how it is possible to transmit FM pulses and simultaneously receive signals, which is another essential development that makes MRI in an extremely inhomogeneous (small) magnet possible.

Selected Publications

D. Idiyatullin, C. Corum, J.-Y. Park, and M. Garwood, Fast and Quiet MRI Using a Swept Radiofrequency, J. Magn. Reson. 181, 342-349, 2006. PMID: 16782371 [abstract]

U. Goerke, M. Garwood, K. Ugurbil, Functional Magnetic Resonance Imaging Using RASER, NeuroImage 54:350-360, 2011. PMCID: PMC2975516 [abstract]

A.L.S. Snyder, C.A. Corum, S. Moeller, N.J. Powell, and M. Garwood, MRI by Steering Resonance through Space, Magn. Reson. Med. 72:49–58, 2014. PMCID: PMC3997623 [abstract]

A. Jang, N. Kobayashi, S. Moeller, J.T. Vaughan, J. Zhang, and M. Garwood, 2D Pulses Using Spatially-Dependent Frequency Sweeping, Magn. Reson. Med. 76:1364–1374, 2016 [abstract]

S.-M. Sohn, J.T. Vaughan, R. L. Lagore, M. Garwood, and D. Idiyatullin, In Vivo MR Imaging with Simultaneous RF Transmission and Reception, Magn. Reson. Med. 76: 1932-1938, 2016 [abstract]

J. Zhang, M. Garwood, and J.-Y. Park, Full Analytical Solution of the Bloch Equation when using a Hyperbolic-Secant Driving Function, Magn. Reson. Med. 77:1630–1638, 2017 [abstract]

J. Zhang, H.L. Ring, K.R. Hurley, Q. Shao, C.S. Carlson, D. Idiyatullin, N. Manuchehrabadi, P.J. Hoopes, C.L. Haynes, J.C. Bischof, and M. Garwood, Quantification and Biodistribution of Iron Oxide Nanoparticles in the Primary Clearance Organs of Mice using T1 Contrast for Heating, Magn. Reson. Med. 78:702-712, 2017 [abstract]

L.J. Lehto, D. Idiyatullin, J. Zhang, L. Utecht, G. Adriany, M. Garwood, Olli Gröhn, S. Michaeli, and S. Mangia, MB-SWIFT Functional MRI during Deep Brain Stimulation in Rats, NeuroImage 159:443-448, 2017 [abstract]

M. Garwood and L. DelaBarre, The Return of the Frequency Sweep: Designing Adiabatic Pulses for Contemporary NMR., J. Magn. Reson. [abstract]

Education

B.A. in biology and chemistry, University of California
Ph.D. in chemistry 1985, University of California