Vuk Mandic is involved in searches for gravitational waves with LIGO. He co-chairs the LIGO group searching for the stochastic background of gravitational waves, which could be cosmological or astrophysical in origin. He is also involved in the studies of different noise sources that limit the performance of gravitational-wave detectors, and is leading a collaboration studying the possibility of building such a detector underground.

Vuk is also involved in the SuperCDMS experiment, where his focus is the R&D of large scale germanium-based detectors for purposes of dark matter search.